RESUMO
OBJECTIVES: Determine the protective effect of oil Helianthus annuus (Sunflower) on myocardial infarction induced by epinephrine in New Zealand rabbits. MATERIALS AND METHODS: The rabbits were randomized into five groups (8 per group): blank, negative control, experimental 1 (10 mg / kg), experimental 2 (20 mg / kg) and three experimental (40 mg/ kg). Experimental groups 1, 2 and 3 received Helianthus annuus oil for two weeks. Epinephrine (2 mg/Kg) to the negative, Experimental Control 1, 2 and 3 groups was given over two consecutive days with an interval of 24 h after pretreatment with oil. Twenty four hours after the last administration, the rabbits were anesthetized and sacrificed. Serum troponin I and polymorphonuclear evaluated by .mu.m.sup.2. RESULTS: Significant difference between the negative control group and the experimental groups 1, 2 and 3 was found in the serum variables troponin I and polymorphonuclear by .mu.m.sup.2. CONCLUSIONS: Helianthus annuus oil at doses of 20 mg/kg has protective effect on myocardial infarction induced by epinephrine in New Zealand rabbits.
Assuntos
Helianthus , Infarto do Miocárdio/prevenção & controle , Fitoterapia , Óleos de Plantas/uso terapêutico , Sementes , Animais , Masculino , Coelhos , Distribuição AleatóriaRESUMO
Objetivos. Determinar el efecto protector del aceite de Helianthus annuus (Girasol) sobre el infarto de miocardio inducido con epinefrina en conejos Nueva Zelanda. Materiales y métodos. Los conejos fueron asignados aleatoriamente en cinco grupos (n= 8 por grupo): blanco, control negativo, experimental 1 (10 mg/kg), experimental 2 (20 mg/kg) y experimental 3 (40 mg/kg). Los grupos experimentales 1, 2 y 3 recibieron aceite de Helianthus annuus durante dos semanas. La epinefrina (2 mg/Kg) se administró a los grupos control negativo, experimentales 1, 2 y 3 durante dos días consecutivos con un intervalo de 24 h después del pretratamiento con aceite. Veinticuatro horas después de la última administración, los conejos fueron anestesiados y sacrificados. Se evaluaron los niveles séricos de troponina I y número de polimorfonucleares por um2. Resultados. Se encontró diferencia significativa entre el grupo control negativo y los grupos experimentales 1, 2 y 3 en los variables niveles séricos de troponina I y número de polimorfonucleares por um2 . Conclusiones: El aceite de Helianthus annuus a dosis de 20 mg/kg tiene efecto protector sobre el infarto de miocardio inducido con epinefrina en conejos Nueva Zelanda.
Objectives. Determine the protective effect of oil Helianthus annuus (Sunflower) on myocardial infarction induced by epinephrine in New Zealand rabbits. Materials and methods. The rabbits were randomized into five groups (8 per group): blank, negative control, experimental 1 (10 mg / kg), experimental 2 (20 mg / kg) and three experimental (40 mg/ kg). Experimental groups 1, 2 and 3 received Helianthus annuus oil for two weeks. Epinephrine (2 mg/Kg) to the negative, Experimental Control 1, 2 and 3 groups was given over two consecutive days with an interval of 24 h after pretreatment with oil. Twenty four hours after the last administration, the rabbits were anesthetized and sacrificed. Serum troponin I and polymorphonuclear evaluated by .mu.m.sup.2. Results. Significant difference between the negative control group and the experimental groups 1, 2 and 3 was found in the serum variables troponin I and polymorphonuclear by .mu.m.sup.2. Conclusions. Helianthus annuus oil at doses of 20 mg/kg has protective effect on myocardial infarction induced by epinephrine in New Zealand rabbits.
Assuntos
Masculino , Animais , Coelhos , Epinefrina , Helianthus , Infarto do Miocárdio , PeruRESUMO
Introducción: El Examen Nacional de Medicina (ENAM) es una herramienta que mide los conocimientos y el raciocinio clínico del interno como una forma de aproximarse a evaluar la calidad educativa. Objetivo: Determinar los factores asociados a la calificación del ENAM 2012 en internos de la Universidad Nacional Mayor de San Marcos (UNMSM). Diseño: Estudio transversal. Lugar: Facultad de Medicina Humana de la UNMSM, Lima, Perú. Participantes: Internos de Medicina Humana 2012. Intervenciones: Se analizó fuentes secundarias con el método de regresión logística binaria. Se determinó los coeficientes de correlación de Pearson y Spearman, así como la prueba t student. Principales medidas de resultados: Promedios de las calificaciones del ENAM, pertenencia a la promoción ingresante, sede hospitalaria de internado, orden de mérito según promedio ponderado universitario (PPU). Resultados: Los factores asociados a un mejor puntaje en el ENAM fueron pertenecer a la promoción ingresante 2006, realizar internado en EsSalud y ubicarse en el tercio superior y medio. Conclusiones: La pertenencia a la promoción ingresante 2006, la sede hospitalaria de internado y el orden de mérito según el PPU fueron factores asociados a obtener una calificación mayor o igual a trece en el ENAM 2012.
Introduction: The National Medical Examination is a tool that measures knowledge and clinical reasoning as an approach to assess educational quality. Objective: To determine factors associated with qualification of the National Medical Examination (ENAM) 2012 at Universidad Nacional Mayor de San Marcos (UNMSM). Design: Cross-sectional study. Setting: Faculty of Human Medicine, UNMSM, Lima, Peru. Participants: Medical Interns 2012. Interventions: Analysis of secondary sources using the binary logistic regression method. Pearson and Spearman correlation coefficients and Student t test were applied. Main outcome measures: ENAMÆs average scores, belonging to the 2006 class, internship hospital, and merit rank according to weighted university average (PPU). Results: Belonging to the 2006 incoming class, doing internship at EsSalud, and be placed in the academic upper and middle third were factors associated with better score at the national exam of medicine. Conclusions: Belonging to the 2006 class, hospital of internship, and merit rank were factors associated to a score of thirteen or more at the national exam of medicine 2012.
